Impact of plasma xanthine oxidoreductase activity in patients with heart failure with preserved ejection fraction
K Watanabe, T Watanabe, Y Otaki, T Shishido… - … heart failure, 2020 - Wiley Online Library
… Impact of the co-morbidity of hyperuricaemia with high xanthine oxidoreductase (XOR)
activity on clinical outcomes in heart failure with preserved ejection fraction. (A) Kaplan–Meier …
activity on clinical outcomes in heart failure with preserved ejection fraction. (A) Kaplan–Meier …
[HTML][HTML] Xanthine oxidoreductase: A leading actor in cardiovascular disease drama
… In heart failure, XOR activity is upregulated as a consequence of its increased expression
induced by inflammatory cytokines, as well as of the augmented substrate supply, due to …
induced by inflammatory cytokines, as well as of the augmented substrate supply, due to …
Xanthine oxidoreductase-mediated injury is amplified by upregulated AMP deaminase in type 2 diabetic rat hearts under the condition of pressure overload
Y Igaki, M Tanno, T Sato, H Kouzu, T Ogawa… - Journal of Molecular and …, 2021 - Elsevier
… to xanthine oxidase, a form that produces cytotoxic reactive oxygen species (ROS) [7,8].
Experimental studies using animal heart failure … We examined whether increased expression of …
Experimental studies using animal heart failure … We examined whether increased expression of …
Prognostic impact of plasma xanthine oxidoreductase activity in patients with heart failure with atrial fibrillation
K Watanabe, T Arimoto, T Watanabe, Y Otaki… - Journal of …, 2023 - Elsevier
… improved by the addition of plasma xanthine oxidoreductase (XOR) activity to the basic
predictors of age, New York Heart … significantly improved by the addition of plasma XOR activity to …
predictors of age, New York Heart … significantly improved by the addition of plasma XOR activity to …
Inhibition of xanthine oxidase in the acute phase of myocardial infarction prevents skeletal muscle abnormalities and exercise intolerance
H Nambu, S Takada, S Maekawa… - Cardiovascular …, 2021 - academic.oup.com
… Reduced exercise capacity is an independent predictor of poor prognosis in patients with
heart failure (HF). Exercise intolerance is partly attributed to skeletal muscle abnormalities, …
heart failure (HF). Exercise intolerance is partly attributed to skeletal muscle abnormalities, …
Characteristics of patients with an abnormally decreased plasma xanthine oxidoreductase activity in acute heart failure who visited the emergency department
A Shirakabe, H Okazaki, M Matsushita, Y Shibata… - Cardiology, 2020 - karger.com
… A highly sensitive assay of human plasma xanthine oxidoreductase activity using stable …
Increased plasma xanthine oxidoreductase activity deteriorates coronary artery spasm. Heart …
Increased plasma xanthine oxidoreductase activity deteriorates coronary artery spasm. Heart …
Time‐dependent changes in plasma xanthine oxidoreductase during hospitalization of acute heart failure
H Okazaki, A Shirakabe, M Matsushita… - … Heart Failure, 2021 - Wiley Online Library
… XOR activity leads to adverse outcomes. However, high-XOR activity was not associated with
increased HF … The time-dependent changes of the high-XOR activity after admission have a …
increased HF … The time-dependent changes of the high-XOR activity after admission have a …
New insights into purine metabolism in metabolic diseases: role of xanthine oxidoreductase activity
M Furuhashi - American Journal of Physiology …, 2020 - journals.physiology.org
… cardiovascular events, heart failure, and renal dysfunction (2, 20, 58). In animal models,
inhibition of XOR activity by allopurinol, febuxostat, or topiroxostat improved cardiovascular and …
inhibition of XOR activity by allopurinol, febuxostat, or topiroxostat improved cardiovascular and …
Xanthine oxidase inhibition attenuates doxorubicin-induced cardiotoxicity in mice
Y Tanaka, T Nagoshi, A Yoshii, Y Oi… - Free Radical Biology …, 2021 - Elsevier
… the cardiac tissue UA level might increase in the failing heart … that cardiac tissue XDH activity
was significantly increased in … significantly reduced cardiac XDH activity (Supplementary Fig…
was significantly increased in … significantly reduced cardiac XDH activity (Supplementary Fig…
[HTML][HTML] Natural mutations of human XDH promote the nitrite (NO2−)-reductase capacity of xanthine oxidoreductase: A novel mechanism to promote redox health?
G Massimo, RS Khambata, T Chapman, K Birchall… - Redox Biology, 2023 - Elsevier
… to alter xanthine oxidoreductase (XOR) activity leading to … conditions also expresses
oxidase activity leading to both O 2 ·… To account for potential technical failure, we increased this …
oxidase activity leading to both O 2 ·… To account for potential technical failure, we increased this …